15 Gene prediction

15 Gene prediction - Introduction to Bioinformatics...

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Introduction to Bioinformatics/ Elements of Bioinformatics Gene prediction
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References Mount D.W. (2004) Bioinformatics: Sequence and Genome Analysis. 2nd ed. Cold Spring Harbor Lab. Press, N.Y. Chapter 9. Baxevanis, A.D., and Ouellette, B.F.F. (2005) Bioinformatics - A practical guide to the analysis of genes and proteins (3rd ed). John Wiley and Sons, NY. Chapter 5. Mathe C., Sagot M-F, Schiex T., and Rouze P. (2002) Current methods of gene prediction, their strengths and weaknesses. Nucleic Acids Research 30: 4103- 4117.
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Gene prediction given a DNA sequence – predict the protein coding regions: which strand is used as template? which reading frame is used? which region is protein coding (exon)? – predict the regulatory regions
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