1471-2156-8-4 - BMC Genetics Database BioMed Central Open...

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Bio Med Central Page 1 of 5 (page number not for citation purposes) BMC Genetics Open Access Database iCartiGD: the Integrated Cartilage Gene Database Ming-Yiu Yeung †1 , David K Smith †1 , Matthew SY Chan 1 , Cheuk M Li 1 , Brian C Wong 1 , Kenneth MC Cheung 2 , Keith DK Luk 2 , Kathryn SE Cheah 1 , Pak Sham 3,4 , Danny Chan 1 and You-Qiang Song* 1,2,4 Address: 1 Department of Biochemistry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Rd, Pokfulam, Hong Kong, China, 2 Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Rd, Pokfulam, Hong Kong, China, 3 Department of Psychiatry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Rd, Pokfulam, Hong Kong, China and 4 Genome Research Centre, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Rd, Pokfulam, Hong Kong, China Email: Ming-Yiu Yeung - [email protected]; David K Smith - [email protected]; Matthew SY Chan - [email protected]; Cheuk M Li - [email protected]; Brian C Wong - [email protected]; Kenneth MC Cheung - [email protected]; Keith DK Luk - [email protected]; Kathryn SE Cheah - [email protected]; Pak Sham - [email protected]; Danny Chan - [email protected]; You-Qiang Song* - [email protected] * Corresponding author †Equal contributors Abstract Background: Diseases of cartilage, such as arthritis and degenerative disc disease, affect the majority of the general population, particularly with ageing. Discovery and understanding of the genes and pathways involved in cartilage biology will greatly assist research on the development, degeneration and disorders of cartilage. Description: We have established the Integrated Cartilage Gene Database (iCartiGD) of genes that are known, based on results from high throughput experiments, to be expressed in cartilage. Information about these genes is extracted automatically from public databases and presented as a single page report via a web-browser. A variety of flexible search options are provided and the chromosomal distribution of cartilage associated genes can be presented. Conclusion: iCartiGD provides a comprehensive source of information on genes known to be expressed in cartilage. It will remain current due to its automatic update capability and provide researchers with an easily accessible resource for studies involving cartilage. Genetic studies of the development and disorders of cartilage will benefit from this database. Background Diseases of cartilage, such as arthritis and degenerative disc disease, affect the majority of the general population, particularly with ageing. In recognition of the impact of musculo-skeletal disorders on society, 2000–2010 has been declared the bone and joint decade by the World Health Organization [1]. One aim of this decade is to fos- ter research relevant to musculo-skeletal systems. Discov- ery and understanding of the genes and pathways involved in cartilage biology will greatly assist research on the development, degeneration and disorders of cartilage.
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