Assignment_2 - Name Lai Mei Kwan Michele UID 2008078522...

Info icon This preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
1 Name: Lai Mei Kwan Michele UID: 2008078522 BSc(Bioinformatics) II BIOC2811 Structural Bioinformatics Assignment 2: Modeling and Analysis of a Protein Sequence of Unknown Structure Protein chosen: protein-arginine deiminase type-6 [Canis lupus familiaris] NCBI Reference Sequence: NP_001091016.1 [http://www.ncbi.nlm.nih.gov/protein/NP_001091016.1] Sequence in FASTA format please refer to the file [protein-arginine_deiminase_type-6_Canis_lupus_familiaris.fasta] Protein chosen for alignment as template (in PDB code): 1WD9-A Biological significance of the target protein and the template protein The protein s name is protein-arginine deiminase type-6 [Canis lupus familiaris]. It is the protein found in DOGS. The template protein is 1WD9, Calcium bound form of human peptidylarginine deiminase type4 (PAD4), which is the homologue found in human. The sequence and 3D structure of 1WD9 is known and resolved respectively. However for the dog s protein, the sequence is only predicted and the 3D structure is for sure unknown. In human, PAD4 is a Ca 2+ -dependent enzyme that catalyzes the conversion of protein arginine residues to citrulline. Its gene is a susceptibility locus for rheumatoid arthritis. The findings identify a novel mechanism for enzyme activation by Ca 2+ ions, and are important for understanding the mechanism of protein citrullination and for developing PAD-inhibiting drugs for the treatment of rheumatoid arthritis.
Image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern