Normal Hematology Part II

Normal Hematology Part II - Click to edit Master subtitle...

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Unformatted text preview: Click to edit Master subtitle style 11 Normal Hematology Part II Dr. Debbie Tucker 22 Leukocytes n Less than 1% of blood volume n Buffy coat n Complete cells with nuclei and organelles n In contrast to red blood cells and platelets n WBC count n 4800-10,800 per cubic millimeter 33 Leukocytes n Protection against injury and infection in blood and in tissue n Diapedesis n Adhesion molecules called selectins on endothelial cells of the capillaries bind to receptors of white blood cells called integrins n Amoeboid motion n Chemotaxis n Leukocytosis n > 11,000 WBCs per cubic millimeter n Leukopenia 44 55 Leukocytes n Granulocytes n Cytoplasmic granules n Phagocytic n Neutrophils n Eosinophils n Basophils n Agranulocytes n Lymphhocytes n Monocytes 66 Leukocytes n Never let monkeys eat bananas n Neutrophils n Lymphocytes n Monocytes n Eosinophils 77 Leukocytes n www.indstate.edu/thcme/PSP/blood/bld- type.jpg 88 Neutrophils n Neutrophils first on the scene n Within 90 minutes of injury n Marginate to sides of blood vessels n Emigration or diapedesis n Die rapidly (6 hours to a few days) 99 Neutrophils n Twice as large as RBCs n Pale lilac cytoplasm n Granular leukocyte but granules hard to see n Take up both basic and acidic dye n Multi-lobed (3-6) nucleus with thin strands of connecting nuclear material 1010 Neutrophils n Granules n 2 types n Lysosomes with hydrolytic enzymes n Defensins n Antibiotic-like proteins n Metabolic pathways that produce toxic substances: hydrogen peroxide and nitric oxide products 1111 Neutrophils n Functions n Inflammatory cell n Phagocytosis n Most active WBC against bacteria and some fungi n Respiratory burst where oxygen is metabolized to bleach and hydrogen peroxide n Defensin-mediated lysis n Peptide spears 1212 Neutrophils n Neutrophils n Segs, PMNs (polymorphonuclear leukocytes, polys) n Bands are the immature form of the mature neutrophil seen in the blood n Neutropenia n Leukocytosis n Increased in neutrophils seen with any inflammatory response n Persistent increase most commonly associated with bacterial infections 1313 Eosinophils n About the same size as neutrophils n Bilobed nucleus (telephone receiver) n Large, coarse granules staining red n Phagocytic n Live 8-12 days n Granules n Lysosome-like n Unique variety of digestive enzymes n Lack enzymes that digest bacteria 1414 Eosinophils n Eosinophils n Key cell in parasitic infections n Release a protein that is toxic to large parasitic worms that cannot be phagocytized n A key control cell in inflammatory reactions, n Eosinophil 1515 Basophils n Rarest of WBCs n Slightly smaller than neutrophils n Granules are large and coarse and stain with basic dyes n Nucleus is deep purple with 2-3 constrictions 1616 Basophils n Nucleus often obscured by granules n Live ? a few hours to a few days 1717...
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This note was uploaded on 07/29/2010 for the course SCI none taught by Professor None during the Spring '10 term at Armstrong State University.

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Normal Hematology Part II - Click to edit Master subtitle...

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