BBm334 GP Paper - BIOBM334 Glycogen Phosphorylase Paper...

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BIOBM334 Glycogen Phosphorylase Paper Degradation of stored glycogen occurs through the action of glycogen phosphorylase (GP). GP phosphorolytically removes single glucose residues from α -(1,4)-linkages within the glycogen molecules. The product of this reaction is glucose-1-phosphate which is then converted to the more usable glucose-6- phosphate by another enzyme. Glycogen phosphorylase is made up of two identical subunits, with each subunit containing a glycogen binding site and a separate active site. The enzyme exists in two forms: phosphorylase a and b, and can exist in two distinct conformational states: an active Relaxed state (R) and a less active Tense state (T). The form of the enzyme that can bind to the glycogen is phosphorylase a and it favors the R states. This conformation is enhanced by binding of AMP and inhibited by binding ATP or glucose-6- phosphate. These are types of allosteric control, which is a type of control where regulatory elements bind to an area other than the active site of the enzyme. In class the allosteric control factors were analyzed and observed in the
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BBm334 GP Paper - BIOBM334 Glycogen Phosphorylase Paper...

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