lecture4b - Borrelia burgdorferi VlsE protein from lyme...

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H 3 C COO - HO H H NH 3 + L-Threonine (2S, 3R) also, don't draw stereochemistry for tetrahedron like this: what geometry is this? H 3 C COO - H 3 CH 2 C H H NH 3 + L-Isoleucine (2S, 3S) Crowded, cell-like environment induces shape changes in an aspherical protein D. Homouz et al. Proc. Natl. Acad. Sci. 2008 , v. 105 , p. 11755
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Unformatted text preview: Borrelia burgdorferi VlsE protein from lyme disease Increased crowding causes a change in native football shape to bent-bean intermediate to a spherical form. This leads to increased exposure of an antibody-recognition site (in green)....
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