lecture15_10_23_08 - Lecture 15 Overview: citric acid cycle...

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Chapter 17: The Citric Acid Cycle Overview: • citric acid cycle overview • post-glycolysis: from pyruvate to acetyl-CoA • CAC • CAC regulation Lecture 15 HW: no problems assigned - focus on understanding reaction mechanisms. Ch. 17 Ch. 18 Three stages of cellular respiration 8 e CAC Citric acid cycle (CAC) = tricarboxylic acid (TCA) cycle = Krebs cycle The fuel molecules enter CAC as acetyl CoA. The oxidative decarboxylation of pyruvate and sequence of reactions in CAC take place in the mitochondrial matrix. The citric acid cycle • occurs in mitochondrial matrix of eukaryotes (glycolysis takes place in cytosol) • also called TCA, or tricarboxylic acid cycle • also called Krebs cycle - intermediates linked to other pathways • fully oxidizes acetate (as acetyl-CoA) to CO 2 • link between glycolysis & TCA mediated by pyruvate dehydrogenase • energy from oxidation conserved as NADH, FADH 2 , and ATP/GTP -the reducing equivalents enter oxidative phosphorylation • cyclical pathway (not linear like glycolysis) -8 reactions (8 enzymes); 4 are oxidations
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pyruvate dehydrogenase (PDH) is a very large complex; multiple
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This note was uploaded on 08/04/2010 for the course CHM 6620 taught by Professor Dr.christinechow during the Fall '08 term at Wayne State University.

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lecture15_10_23_08 - Lecture 15 Overview: citric acid cycle...

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