lecture18_11_6_08 - Lecture 18 Overview glycogen breakdown...

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Chapter 21: Glycogen Metabolism Lecture 1 8 Overview: • glycogen breakdown requires interplay of several enzymes • glycogen is synthesized and degraded by different pathways epinephrine and glucagon signal the need for glycogen breakdown • glycogen breakdown and synthesis are reciprocally regulated The structure and function of glycogen Glycogen is the stored form of glucose. It is a very large, branched polymer of glucose residues. Most of the linkages are ! -1,4- glycosidic bonds, but ! -1,6-glycosidic bonds occur approximately every ten residues. The controlled release of glucose from glycogen maintains blood-glucose levels between meals. The fates of glucose 6-phosphate 1) fuel for anaerobic or aerobic metabolism (muscle) 2) converted to free glucose in the liver and released into the blood 3) processed by the pentose phosphate pathway to generate NADPH or ribose in a variety of tissues Glycogen breakdown Glycogen breakdown requires 4 enzymes: glycogen phosphorylase , debranching enzymes (
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lecture18_11_6_08 - Lecture 18 Overview glycogen breakdown...

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