Bio 575 chapter 15 07

Bio 575 chapter 15 07 - Chapter 15 Robert Arking Biology of...

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Chapter 15 Robert Arking Biology of Aging, 3e Oxford University Press Wayne State University
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One major lesson learned from our survey of modern biogerontology is that the senescence process can be significantly delayed via the appropriate modification of well known cell signaling and transduction pathways. This lesson implies that pharmecutical anti-aging interventions are possible. In fact, the first drugs deserving of this name are already on the market. It seems reasonable to conclude that many people will opt for such treatment in the next few decades, especially as improved anti-aging drugs are developed. So we can look forward to a significant increase in longevity . Which is a good thing .
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But what about… overpopulation? Overpopulation occurs in the non- developed world, not the developed world.
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The Dynamics of the Demographic Transition
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Thesis : The life  expectancy at birth is  projected to keep  increasing                          After Oeppen and Vaupel 2002 Antithesis : The  historical increases in  mean lifespan are  cease. 2004
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Three Longevity Phenotypes: Increased Early Survival Selection for toxin resistance  yields an increase in mean  life span but not in  maximum. The life span changes are  due to a decrease in early  life mortality but not in late  life mortality.              after Arking et al., 2004
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Three Longevity Phenotypes: Increased Late Survival Heat shock treatment  yields no change in the  mean life span but an  increase in maximum life  span The life span changes  are due to a decrease in  the late life age specific  probability of death. after Arking et al., 2004
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Three Longevity Phenotypes: Delayed Onset of Senescence Selection for longevity yields an  increase in the ‘health span’ but  no effect on the ‘senescent  span’. The life span changes are due to  delayed onset of the midlife  increase in the age specific  mortality probability, giving rise  to an extended ‘health span’  MRDT = ~9 days vs ~6 days after Arking et al., 2004
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Mathematical Modeling Simulates the Three Phenotypes… by decreasing the oxidative  vulnerability by decreasing the external  (non-age related) mortality by increasing the energy  investment into somatic repair                     after Arking et al., 2004 CR mice,   no human example Outbred mice, human  centenarians
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These Data Show That . . .
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Bio 575 chapter 15 07 - Chapter 15 Robert Arking Biology of...

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