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Bio 575 chapter 14 Slides 07

Bio 575 chapter 14 Slides 07 - Chapter 14 Robert Arking...

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Chapter 14 Robert Arking Biology of Aging, 3e Oxford University Press Wayne State University
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Lamb’s Linear Model: 1. Stochastic damage occurs 2. Repair processes respond 3. Repair processes become less efficient with age 4. Unrepaired damage accumulates with age 5. Cell’s ability to function becomes increasingly impaired 6. Decreased cellular efficiency leads to decreased functional capacity of tissues, organs, organ systems. 7. Ability of the organism to cope with environmental demands becomes progressively diminished. Probability of death increases to a near-certainty.
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1 yr
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Epicellular Interactions
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Concepts dealt with as part of the standard Evolutionary Theory 1. Principles of Senescence 2. Principles of Mortality 3. Principles of Longevity 4. Biodemographic Principles & Human Longevity 5. Proximate Determinants of Human Longevity 6. Longevity Gains are Self-reinforcing.
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Longevity Itself Can Be Indirectly Selected by Two Different Mechanisms 1. Environmentally Selected Life Spans: Conditions of resource uncertainty &/or scarcity 2. Socially Selected Life Spans: Conditions of kinship, cooperation, parental care, monogamy, and helpers.
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