Bio 575 chapter 12 07

Bio 575 chapter 12 07 - Chapter 12 Robert Arking Biology of...

Info iconThis preview shows pages 1–23. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Chapter 12 Robert Arking Biology of Aging, 3e Oxford University Press Wayne State University Cells & Aging :Historical Background Ross Harrison Carel & Ebeling Earle, Gey Hayflick & Moorhead Note: this opposes the view that aging is an organismal level problem. It thus is a paradigm shift in the field . It is likely more accurate to view it as the antithesis to the pre-existing thesis (& the obligatory synthesis will be discussed in due course) Hypothesis: the visible and functional manifestations of aging in organisms have an intracellular basis Cells can survive for longer periods of time than did the donor organisms from which they were maintained. Mouse skin or mammary tissue Human organ transplants Cells can be functional even when proliferative ability has greatly decreased But loss of proliferative ability is associated with significant changes in cell physiology: = cell senescence. Question: does cell senescence have anything to do with organism senescence? 1. Is there a correlation between donor age & replicative senescence? 2. Is there a correlation between a species maximum life span and the maximum number of PDs its cells may undergo? 1. Do all cells of a certain replicative age behave in the same manner? 2. Are these processes autonomous to the cell? 3. Are the processes involved in replicative senescence in vitro closely related to senescent processes in situ ? 1. Is there a correlation between donor age & replicative senescence? . PROBABLY NOT 2. Is there a correlation between a species maximum life span and the maximum number of PDs its cells may undergo?... NO 1. Do all cells of a certain replicative age behave in the same manner? 1. Are the processes involved in replicative senescence in vitro closely related to senescent processes in situ ? 2. Are these processes autonomous to the cell? After J.R. Smith, 19xx There is no intracellular clock 1. Is there a correlation between donor age & replicative senescence?.... PROBABLY NOT 2. Is there a correlation between a species maximum life span and the maximum number of PDs its cells may undergo?... NO 3. Do all cells of a certain replicative age behave in the same manner?..... NO 4. Are these processes autonomous to the cell? 5. Are the processes involved in replicative senescence in vitro closely related to senescent processes in situ ? On next slide: Age-dependent Distribution of Fibroblast Cells in the Skin of Human Donors Age yrs MFI MFII MFIII Sum MF PMF IV PMF V PMF VI Sum PMF 10 15 59 13 87 3 1 9 13 30 7 54 12 73 11 3 13 27 50 38 30 68 6 7 19 32 70 6 39 45 14 5 36 55 90 2 12 14 21 8 57 86 1.1....
View Full Document

Page1 / 63

Bio 575 chapter 12 07 - Chapter 12 Robert Arking Biology of...

This preview shows document pages 1 - 23. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online