Bio 575 chapter 11 07

Bio 575 chapter 11 07 - Chapter 11 Robert Arking Biology...

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Chapter 11 Robert Arking Biology of Aging, 3e Oxford University Press Wayne State University
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What Accounts for Systemic Aging if Not An Aging Program Affecting Some Global Trait Such as Metabolism? Development is a programmed activity; why not aging?
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RATE OF LIVING THEORY Buffon 1749; Pearl 1928 Assumption: All cells have the same fixed amount of energy Predictions: 1. There is a predetermined available amount of energy for every cell and death will occur when this quantity is used up. 2. There is an inverse relationship between metabolic rate & longevity
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Disproof of Prediction 1
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Disproof of Prediction 2
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Disproof of Major Assumption The metabolic potential varies for different populations of the same species
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MITOCHONDRIAL DAMAGE THEORIES Blends together evidence for the role of oxidative damage with the production of ROS in the mitochondria, and with the details of mitochondrial structure and function. The result is the Mitochondrial Free Radical Theory of Aging
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EMF Leakage A small decrease in EMF large decrease in leakage
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H+ HEAT UCP1 UCP2,3 Metabolic signals passive leaks Sources of Proton Leaks
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33 mo AL 33 mo CR Body wt 446g 262g O 2 leakage (IV) 1.0 0.77 Proton EMF 1.0 ~1.0
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This note was uploaded on 08/05/2010 for the course BIO 5750 taught by Professor Arking during the Winter '09 term at Wayne State University.

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Bio 575 chapter 11 07 - Chapter 11 Robert Arking Biology...

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