Bio 575 chapter 06 09

Bio 575 chapter 06 09 - Chapter 6 Nutrition Exercise...

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Chapter 6 Nutrition Exercise Antioxidant Therapy
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Diet Lifespan # Alive at % change in Mean Median 1200 days median lifespan m f m f # at day 1 m f Normal 509 801 522 820 0/36 ----- DR from 72+ 755+ 797 904 8/36 +53% +10% weaning DR from 883+ 824+ 919 894 5/34 +76% -9% After McCay and Crowell 1935 Effect of DR on Lifespan of Rats
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Premature mortality Delayed Onset of Senescence
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Wistar male rat, AL diet, 1010 days old Wistar male rat, DR diet, 1248 days old Function Follows Form
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The same AL individual may display both normal & damaged muscle fibers.
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What Happens If DR Is Not Started Until Midlife?
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Diet Food Body Wt Fat Collagen Longevity g/day g % wt Denatur. Mean Maximum Time (m) AL Obese 4.2 59 67 80 552 890 AL Normal 3.0 30 22 52 799 970 DR Obese 2.0 28 48 30 814 1300 DR Normal 2.0 20 13 5 810 1280 From Harrison et all, 1984 Note that DR can yield Extended Longevity in the presence of obesity
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B6 DR << B6 AL Not all strains respond to DR – it is not a universal antidote to aging!
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No Thus CR must be affecting some basic physiological and/or cellular mechanisms
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X X X
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levels of corticosteroids may inhibit pathways which increase inflammation in cells. HORMESIS?
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Bio 575 chapter 06 09 - Chapter 6 Nutrition Exercise...

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