MassSpecSummary - FUNDAMENTALS OF MASS SPECTROMETRY I....

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FUNDAMENTALS OF MASS SPECTROMETRY I. BASIC CONCEPTS IN MASS SPECTROMETRY Mass spectrometry measures the mass to charge ratio of ions. Since the charge is usually unity, the mass of a species is obtained directly. Typical Mass Spectrum: Signal Intensity Mass to Charge Ratio Base Peak Molecular Ion The mass spectrum shows the fragmentation pattern of the molecular ion (the ion derived from the neutral molecule under study) and hence is quite dependent on the molecular structure. Molecular ions (parent ions) are not always seen. This typically occurs when the molecular ion is not stable as a charged species. Instead, many daughter ions are observed. II. LOW RESOLUTION MASS SPECTROMETRY Low resolution mass spectrometry measures masses to only unit mass resolution. The signals in a mass spectrum arise from detection of individual ions. Therefore, ions from chloromethane such as 12 CH 3 35 Cl, 13 CH 3 35 Cl, 12 CH 3 37 Cl, and , 12 CH 2 D 37 Cl are all different and would appear as signals at mass to charge ratios of 50, 51, 52, and 53. Therefore, do not use
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MassSpecSummary - FUNDAMENTALS OF MASS SPECTROMETRY I....

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