ENGR 213.lecture 3.students

ENGR 213.lecture 3.students - Bioengineering at the...

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Click to edit Master subtitle style Bioengineering at the Cellular  Level Specialized organization of molecules
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Admin n  Read Chapter 4,5     
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Learning Objectives n Describe  the major cellular components n Calculate  osmolarity and the conditions  for cellular equilibrium
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Cell Constituents n Cell Membrane is highly  structured n Cell is highly  specialized n Nucleus n Mitochondria n Golgi Apparatus n Centriole
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Cell Organization n Plasma Membrane is the boundary between  inside and outside of the cell n Composition:  Approximately 60% water.  The  inorganics n Eukaryotic-cell nucleus is surrounded by a  membrane (animal cells) n Prokaryotic-single cellular chromosome or 
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Organelles n Specialized part of the cell that performs a  specific function n Golgi Apparatus – packager n Mitochondria – energy producer  n Lysosome – digests waste materials and food  within the cell n Endoplasmic reticulum  –  n Ribosomes – Cellular organelle that is the site of 
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Plasma Membrane n Selectively permeable n Site of transport into and out of the cell n Osmosis n Vesicles
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Osmosis n Transport of a solvent (usually water,  but not a requirement) through a  selectively permeable membrane n Purpose is to equalize concentrations  on either side of the membrane n Osmolarity – concentration of  osmotically active particles in solution
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Equilibrium in cells n Internal and external osmolarities are  equal n Charge inside and outside are equal n Cell membranes are slightly permeable  to sodium  n Energy is used by the cell to maintain 
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Vesicle Transport n Exocytosis – Transport of large  substances out of the cell by crossing  the plasma membrane n Endocytosis – Transport of large  substances into the cell by crossing the  plasma membrane
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Cellular response to force n Tissues grow and adapt in response to  mechanical loading n Engineers have developed a means to  quantify cellular response by culturing  cells in the presence of a flow field n Can lead to better engineered tissue 
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Determination of Cell  Properties n Micropipette aspiration is performed to  determine the mechanical properties of single  cells.  n Chondrocytes are isolated from the  extracellular matrix using enzymatic digestion n A microscopic pipette (5 µm diameter) is used  to apply a small pressure to the cell surface, 
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Micropipette Aspiration n In combination with  a theoretical  analysis, the  viscoelastic  properties of the cell  can be determined  with this experiment.  n http://www.mae.ufl.e
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Finite Element Analysis n To determine the nature of the interactions  between the chondrocyte, the pericellular 
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ENGR 213.lecture 3.students - Bioengineering at the...

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