ENGR 213.lecture 3.students

ENGR 213.lecture 3.students - Bioengineering at the...

Info icon This preview shows pages 1–16. Sign up to view the full content.

View Full Document Right Arrow Icon
Click to edit Master subtitle style Bioengineering at the Cellular  Level Specialized organization of molecules
Image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Admin n  Read Chapter 4,5     
Image of page 2
Learning Objectives n Describe  the major cellular components n Calculate  osmolarity and the conditions  for cellular equilibrium
Image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Cell Constituents n Cell Membrane is highly  structured n Cell is highly  specialized n Nucleus n Mitochondria n Golgi Apparatus n Centriole
Image of page 4
Cell Organization n Plasma Membrane is the boundary between  inside and outside of the cell n Composition:  Approximately 60% water.  The  balance being organic compounds & traces of  inorganics n Eukaryotic-cell nucleus is surrounded by a  membrane (animal cells) n Prokaryotic-single cellular chromosome or 
Image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Organelles n Specialized part of the cell that performs a  specific function n Golgi Apparatus – packager n Mitochondria – energy producer  n Lysosome – digests waste materials and food  within the cell n Endoplasmic reticulum  –  storage site & transport n Ribosomes – Cellular organelle that is the site of 
Image of page 6
Plasma Membrane n Selectively permeable n Site of transport into and out of the cell n Osmosis n Vesicles
Image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 8
Osmosis n Transport of a solvent (usually water,  but not a requirement) through a  selectively permeable membrane n Purpose is to equalize concentrations  on either side of the membrane n Osmolarity – concentration of  osmotically active particles in solution
Image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Equilibrium in cells n Internal and external osmolarities are  equal n Charge inside and outside are equal n Cell membranes are slightly permeable  to sodium  n Energy is used by the cell to maintain  charge neutrality
Image of page 10
Vesicle Transport n Exocytosis – Transport of large  substances out of the cell by crossing  the plasma membrane n Endocytosis – Transport of large  substances into the cell by crossing the  plasma membrane
Image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Cellular response to force n Tissues grow and adapt in response to  mechanical loading n Engineers have developed a means to  quantify cellular response by culturing  cells in the presence of a flow field n Can lead to better engineered tissue  replacements
Image of page 12
Determination of Cell  Properties n Micropipette aspiration is performed to  determine the mechanical properties of single  cells.  n Chondrocytes are isolated from the  extracellular matrix using enzymatic digestion n A microscopic pipette (5  µ m diameter) is used  to apply a small pressure to the cell surface,  and the ensuing deformation is recorded 
Image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Micropipette Aspiration n In combination with  a theoretical  analysis, the  viscoelastic  properties of the cell  can be determined  with this experiment.  n http://www.mae.ufl.e
Image of page 14
Finite Element Analysis n
Image of page 15

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 16
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern