MCDB1B Lecture 1

MCDB1B Lecture 1 - MCDB1B Lecture 1 August 2 2010 Animal and Plant Physiology Professor Low Office hours LSB 2111 Mon and Wed 2-3pm Exam 1= August

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MCDB1B Lecture 1 19:28 August 2, 2010 Animal and Plant Physiology Professor Low Office hours: LSB 2111 Mon and Wed 2-3pm Exam 1= August 23 Exam 2= Sept 10 Animal Hormones Anabolic Steroi/Testosterone Abuse Provides optimum concentration in order for us to liver in whatever environment Hormones Chemical messages that allow slow communication between distant cells in body o Slow compared to electrical impulses o Nerves respond in milliseconds
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Act on a time scale of several seconds to days o Gradual changes o Control longer-term physiological processes not instantaneously o Not useful for controlling rapid actions What produces hormones? Endocrine cells Hormone-secreting cells, secret hormones into the interstitial space or blood stream Exocrine cells secret substances into ducts, connected to external (skin, tears) Examples: skin, salivary glands all released through ducts o Lungs continuous with outside environment Circulating hormones: affects far away Secret hormones into extracellular fluids and diffuses into bloodstream, diffuse to different cells of body if and only if contain receptors, if cells have receptors hormones are able to bind and affect the cells, if no receptors, then they cannot bind, from bloodstream will diffuse to proper cells Local hormones: bind receptors on cells on themselves, paracrine hormones diffuse from site of release and bind in short distances (nearby) auto/paracrine hormones released in tiny amounts, produce tiny amounts, hormones broken down nearby circulating hormones diffuse into blood to distribute throughout body need a receptor in order to respond, when it binds it triggers a response one hormone can diffuse different affects in the cell example: epinephrine known as adrenaline where nervous system reacts to an emergency very fast, increases heart rate hormones and their action
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epinephrine acts on different cells in body: o stimulates faster and stronger heartbeat o blood vessels constrict to send more blood to muscles o liver, glycogen is broken down to glucose provides quick energy groups of hormones (1) peptides or proteins o water soluble transported by vesicles ouf of cell that made them o peptide hormone receptors are localized in surface o example: growth hormone, insulin: glucose concentration regulation (2) steroid hormones o lipid-soluble and membrane –permeable o diffuse out of cell o diffuse into target cells o blood must be bound to carrier proteins o receptors for lipid-soluble hormones are inside cells, IN cytoplasm/nucleus o example: estrogen: females sex hormones (3) amine hormones o derivatives of amino acid o epinephrine two locations for receptors receptors for polypeptide hormones
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receptors for watersoluble proteins are large glycoprotein’s on cell surface with 3 domains o binding domain projecting outside plasma membrane o transmembrane domane anchors receptor in membrane o cytoplasmic domain extends in to cytoplasm of cell
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This note was uploaded on 08/14/2010 for the course BIO 2010 taught by Professor Le during the Summer '10 term at UCSB.

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MCDB1B Lecture 1 - MCDB1B Lecture 1 August 2 2010 Animal and Plant Physiology Professor Low Office hours LSB 2111 Mon and Wed 2-3pm Exam 1= August

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