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Unformatted text preview: 96:1638-1645, 2006. First published May 10, 2006; doi:10.1152/jn.00347.2006 J Neurophysiol Fromherz M. Hutzler, A. Lambacher, B. Eversmann, M. Jenkner, R. Thewes and P. You might find this additional information useful... for this article can be found at: Supplemental material http://jn.physiology.org/cgi/content/full/00347.2006/DC1 34 articles, 8 of which you can access free at: This article cites http://jn.physiology.org/cgi/content/full/96/3/1638#BIBL 2 other HighWire hosted articles: This article has been cited by [PDF] [Full Text] [Abstract] , July 1, 2008; 100 (1): 346-357. J Neurophysiol I. Schoen and P. Fromherz Channels by Weak Capacitive Currents on a Silicon Chip Extracellular Stimulation of Mammalian Neurons Through Repetitive Activation of Na+ [PDF] [Full Text] [Abstract] , December 1, 2008; 100 (6): 2977-2980. J Neurophysiol A. C. Kwan What Can Population Calcium Imaging Tell Us About Neural Circuits? including high-resolution figures, can be found at: Updated information and services http://jn.physiology.org/cgi/content/full/96/3/1638 can be found at: Journal of Neurophysiology about Additional material and information http://www.the-aps.org/publications/jn This information is current as of September 24, 2009 . http://www.the-aps.org/. American Physiological Society. ISSN: 0022-3077, ESSN: 1522-1598. Visit our website at (monthly) by the American Physiological Society, 9650 Rockville Pike, Bethesda MD 20814-3991. Copyright © 2005 by the publishes original articles on the function of the nervous system. It is published 12 times a year Journal of Neurophysiology o n S e p t e m b e r 2 4 , 2 9 j n . p h y s i o l o g y . o r g D o w n l o a d e d f r o m Innovative Methodology High-Resolution Multitransistor Array Recording of Electrical Field Potentials in Cultured Brain Slices M. Hutzler, 1, * A. Lambacher, 1, * B. Eversmann, 2 M. Jenkner, 2 R. Thewes, 2 and P. Fromherz 1 1 Max Planck Institute for Biochemistry, Department of Membrane and Neurophysics, Martinsried/Munich, Germany; and 2 Infineon Technologies, Corporate Research, Munich, Germany Submitted 4 April 2006; accepted in final form 8 May 2006 Hutzler, M., A. Lambacher, B. Eversmann, M. Jenkner, R. Thewes, and P. Fromherz. High-resolution multitransistor array recording of electrical field potentials in cultured brain slices. J Neurophysiol 96: 1638–1645, 2006. First published May 10, 2006; doi:10.1152/jn.00347.2006. We report on the recording of electrical activity in cultured hippocampal slices by a multitransistor array (MTA) with 16,384 elements. Time-resolved imaging is achieved with a resolution of 7.8 m on an area of 1 mm 2 at 2 kHz. A read-out of fewer elements allows an enhanced time resolution. Individual transistor signals are caused by local evoked field potentials. They agree with micropipette measurements in amplitude and shape. The spatial continuity of the records provides time-resolved images of evoked field potentials and allows the detection of functional corre-...
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