Weed67

Weed67 - From www.bloodjournal.org at ARIZONA STATE UNIV on...

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1967 29: 297-312 ROBERT I. WEED and ANTHONY J. BOWDLER the Volumes of Human Erythrocytes The Influence of Hemoglobin Concentration on the Distribution Pattern of http://bloodjournal.hematologylibrary.org/misc/rights.dtl#repub_requests Information about reproducing this article in parts or in its entirety may be found online at: http://bloodjournal.hematologylibrary.org/misc/rights.dtl#reprints Information about ordering reprints may be found online at: http://bloodjournal.hematologylibrary.org/subscriptions/index.dtl Information about subscriptions and ASH membership may be found online at: . Hematology; all rights reserved Copyright 2007 by The American Society of DC 20036. by the American Society of Hematology, 1900 M St, NW, Suite 200, Washington Blood (print ISSN 0006-4971, online ISSN 1528-0020), is published semimonthly For personal use only. at ARIZONA STATE UNIV on October 6, 2009. www.bloodjournal.org From
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B L 00 D The Journal of MARCH, 1967 VOL. Hematology XXIX. NO. 3 The Influence of Hemoglobin Concentration on the Distribution Pattern of the Volumes of Human Erythrocytes By ROBEIIT I. W1D ANI) ANThoNY J. BOWDLEB p RIOR TO THE DEVELOPMENT of the electronic particle counter, studies of the dimensions of the red cell were largely confined to the mean values of the populations studied. Attempts to describe the distribution of a property’ within a cell population were made largely as the result of laborious procedures, such as the construction of Price-Jones curves, and were often relatively insensitive, allowing comparisons useful only within broad limits. Electronic particle counting has made practicib1e the counting and sizing of large populations of small particles, including red cells.’-4 The study of the volume distribution of red cells from hematologicallv normal and abnormal subjects has shown a well-defined skewness with a positive extension into the higher size ranges.’4 This skewness has led to further examination of the possible cause of asymmetry, and especially to the consideration of whether cell aging contrll)utes to the skewness. Briefly, this problem can be most simply defined iii relation to the red cell popiilatioii of normal man, in which cell destruction is predominantly Iw mechanisms of senescence, and can be partly resolved into the prol)len1 of whether each cohort of cells carries its own contribution to the total asymmetry when it enters the circulation, or whether the process of aging alters the cells in some fashion such that it is these altered cells which distort the volume distribution of the whole. Lushbaugh, Basmann, and Glascock4 and Winter and Sheard have sug- I’rom the Departments of Radiation Biology and Biophysics and of h’dicinc, University of Rochester School of Medicine and Dentistry, Rochester, Nc’w )ork. Presented
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Weed67 - From www.bloodjournal.org at ARIZONA STATE UNIV on...

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