302%20Exam%204%202010%20vA%20answered

302%20Exam%204%202010%20vA%20answered - Name: _ BIOL302...

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Name: _____________________________ BIOL302 Spring 2010 Exam 4 ID: A 1 302 Exam 4 2010 Multiple Choice: Identify the single best answer for the question. 1) Which is true about a SNP? a) it is caused by slippage druing DNA replication b) it always alters the amino acid sequence of a protein c) it could lead to a RFLP d) two of the above e) all of the above 2) What of the following pairs of sequences (from two different individuals) would be alleles of a Simple Tandem Repeat Polymorphism? 1. ATGAATTCGG and ATGAAATCGG 2. ATGAATTCGG and AAGAATTCGG 3. GAAGAAGAA and GAAGAAGAAGAA 4. GAAGAAGAA and CAAGAAGAA 5. GGGGGGGG and GGAGGGGG a) pair #1 b) pair #2 c) pair #3 d) pair #4 e) pair #5 3) Why do alterations affecting expression of the Bcl2 gene contribute to cancer? a) because overexpression of Bcl2 leads to too much apoptosis, causing excess DNA damage b) because overexpression of Bcl2 leads to inappropriate activation of growth factor signaling pathways c) because overexpression of Bcl2 leads to an increase in chromosomal abnormalities like translocations d) because overexpression of Bcl2 leads to cancer cells being unable to undergo apoptosis, even when their DNA is damaged e) because overexpression of Bcl2 leads to phosphorylation of Rb and premature entry into S phase
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Name: _____________________________ BIOL302 Spring 2010 Exam 4 ID: A 2 4) What is a GTPase? a) a protein that polymerizes GMP b) a protein that cleaves GTP c) a protein that makes GTP d) a protein that cleaves GDP e) a protein that phosphorylates GDP 5) A ‘probe’ in molecular biology usually refers to a) a molecule used in a nucleic acid hybridization reaction to identify a specific DNA fragment b) a molecule that kills bacteria that have not taken up plasmid DNA c) an instrument used to manipulate cells in tissue culture d) a laser that can dtermine the colorof fluorescent tags during automated (by a machine) DNA sequencing e) a molecule that can cause cancer cells to undergo apoptosis 6) Tumor-suppressor genes normally control a) telomerase actvity b) sister chromatid separation c) the cell cycle or apoptosis d) DNA polyermase processivity e) protein degradation 7) Which of the following could be a polymorphic site in the human genome? a) a difference in copy number of a simple sequence repeat b) a single base pair deletion c) a single base pair change d) two of the above e) all off the above 8) How is DNA ligase used in recombinant DNA technology? a) to cleve DNA at specific sequences b) to make cells resiatant to antibiotics c) to polymerize the template strand during PCR d) to seal the nicks in the sugar phosphate backbone of recombinant plasmids e) to add a phosphate to ends generated by restriction enzymes
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Name: _____________________________ BIOL302 Spring 2010 Exam 4 ID: A 3 9) After 30 cycles of amplification by PCR, approximately how many molecules of the target DNA are present if there was one molecule of template to start and the PCR reaction steps are 100% efficient? a)
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302%20Exam%204%202010%20vA%20answered - Name: _ BIOL302...

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