05LargeMolecules3-1

05LargeMolecules3-1 - Lecture 5 Large Molecules 3: Proteins...

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Lecture 5 Large Molecules 3: Proteins
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Proteins are polymers of amino acids . Proteins range in size from a few amino acids to thousands of them (titin = 38000 amino acids). Folding is crucial to the function of a protein and is influenced largely by the sequence of amino acids.
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All 20 amino acids have the structure: H + H 3 N–C α –COO R at cytoplasmic pH!
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Formation of Peptide Linkages Start!! End!!
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This results in a peptide backbone consisting of repeating units of atoms: C α —C—N—C α —C—N. The precise sequence of amino acids is called its primary structure .
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Enormous numbers of different proteins are possible: 20 kinds of amino acids; 100 aa in one protein = 20 100 = 10 130 possible combinations.
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The Twenty Amino Acids Found in Proteins (Part 1)
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The Twenty Amino Acids Found in Proteins (Part 2)
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The Twenty Amino Acids Found in Proteins (Part 3)
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A protein’s secondary structure consists of regular, repeated patterns in different regions in the polypeptide chain. This shape is determined primarily by hydrogen
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05LargeMolecules3-1 - Lecture 5 Large Molecules 3: Proteins...

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