06Membranes - Lecture 6 Membranes Membrane Structure...

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Lecture 6 Membranes
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Membrane Structure Membrane Function (passive and active transport)
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A Phospholipid Bilayer Separates Two Aqueous Regions Membrane Structure Cholesterol has a rigid ring structure which makes the membrane more solid (counteracts the effect of unsaturated fatty acids).
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It is energetically favorable for bilayers to seal, that is to form an enclosed space
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A two-dimensional fluid Four types of movement: Lateral diffusion most important Flip-flop: Very rare because hydro- philic head has to cross hydrophobic interior. Flexion Rotation Fluidity important for cell shape changes and lateral diffusion of membrane proteins
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extracellular glycolipid Some proteins bind to specific cytosolic phospholipids Phospholipids and glycolipids are asymmetrically distributed; sugar modifications are added in Golgi, therefore on outer surface
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The fluid mosaic model: a mosaic of proteins embedded in a two-dimensional fluid How do proteins insert into the membrane? By exposing hydrophobic amino acids in transmembrane areas.
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Transmembrane proteins have hydrophobic regions of amino acids that cross the phospholipid bilayer. They have a specific orientation, showing
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This note was uploaded on 08/21/2010 for the course BIOLOGY biol 112 taught by Professor Dent during the Winter '09 term at McGill.

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06Membranes - Lecture 6 Membranes Membrane Structure...

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