{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

10glycolysis-1 - Lecture 10 Enzyme Regulation and...

Info icon This preview shows pages 1–10. Sign up to view the full content.

View Full Document Right Arrow Icon
Pathway and Enzyme Regulation Redox reactions Glycolysis Lecture 10 Enzyme Regulation and Glycolysis
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
End-product or feedback inhibition regulates the whole pathway Regulation of metabolic pathways
Image of page 2
Principles governing metabolic pathways: Each reaction in the pathway is catalyzed by a specific enzyme. The operation of each metabolic pathway can be regulated by the activities of key enzymes.
Image of page 3

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Multiple feedback control allows cells to adjust the ratio of different compounds (e.g. amino acids)
Image of page 4
Enzyme activity can be inhibited by natural and artificial binders Naturally occurring inhibitors regulate metabolism Irreversible inhibition occurs when the inhibitor destroys the enzyme’s ability to interact with its normal substrate Enzyme Regulation
Image of page 5

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
DIPF, a nerve gas, irreversibly inhibits acetylcholinesterase
Image of page 6
When an inhibitor binds reversibly to an enzyme’s active site, it competes with the substrate for the binding site and is called a competitive inhibitor When an inhibitor binds reversibly to a site distinct from the active site, it is called a noncompetitive inhibitor or negative allosteric regulator ; they act by changing the shape of the enzyme in such a way that the active site can no longer bind the substrate Allosteric regulators can stabilize the inactive form as described above, but they can also stabilize the active form (positive allosteric regulator)
Image of page 7

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 8
An allosteric regulator!
Image of page 9

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 10
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern