Colley - Lec 9 - Post-translational modification - 2010

Colley - Lec 9 - Post-translational modification - 2010 -...

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Lecture 9 Protein Post-Translational Modification and Introduction to Protein Trafficking in the Cell Karen Colley 2020 MBRB karenc@uic.edu
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After Incorporation into Peptide Chains, Amino Acids can be Modified
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Asn, Ser and Thr can be Enzymatically Glycosylated: N-linked Glycosylation on Asn
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Asn, Ser and Thr can be Enzymatically Glycosylated: O-linked Glycosylation on Ser and Thr
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The Roles of the Oligosaccharides on Glycoproteins * Protein Targeting : Mannose 6-phosphate dependent targeting of lysosomal enzymes. * Protein Clearance : GalNAc-4-SO 4 -dependent clearance of glycoprotein hormones. * Mediating Cell Interactions : Glycan-Selectin dependent cell-cell interactions in inflammation and lymphocyte homing. * Modulating Cell Adhesion : The polysialylation of NCAM reduces cell adhesion during development and in cancer. * Modulating Protein Function : The glycosylation of the Notch receptor modulates its ability to control cell fate and proliferation decisions. * Protein Quality Control : The glycans on newly made proteins act as signals for folding status and determine their interaction with chaperones and retention in the ER. * Receptors : Cell surface glycans act as receptors for viruses and toxins.
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Amino groups of amino acids can be Non-enzymatically Glucosylated
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The percentage of non-enzymatically glucosylated Hemoglobin (Hb A1c) found in the blood of diabetics is used to evaluate their long term management of blood glucose levels. % Hb A1c Average Blood Glucose (mg/ dl) Seriously Elevated Levels 11-14 310-415 Elevated Levels 8-10 205-275 In Control 7 170 Non-Diabetic Levels 4-6 65-135
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Proteins can be anchored to the membrane by hydrophobic amino acid stretches or by lipophilic modifications Fatty acid acylation: Myristate Palmitate Prenylation: Farnesyl Geranylgeranyl GPI Anchor
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This note was uploaded on 08/21/2010 for the course BMS 652 taught by Professor Dr.yee-kinho during the Fall '10 term at University of Illinois at Urbana–Champaign.

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Colley - Lec 9 - Post-translational modification - 2010 -...

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