04-28 - 04/28/09 Major neurotransmitters o o o o...

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04/28/09 Major neurotransmitters o Acetylcholine o Biogenic amines o Amino acids o Neuropeptides Acetylcholine o CNS o PNS o Neuromuscular junction Acetylcholine receptor types o Muscarinic receptor o Nicotinic receptor Biogenic amines o Norepinephrine (noradrenaline) Also a hormone produced by the adrenal medulla Excitatory or inhibitory o Dopamine Generally excitatory o Serotonin Generally inhibitory Amino acids o GABA Inhibitory
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o Glycine Inhibitory o Glutamate Excitatory o Aspartate Excitatory Neuropeptides o Substance P Excitatory- mediates perception of pain o Endorphins Inhibitory- inhibits the perception of pain Gas molecules as signals Nitric oxide (NO) o NO causes blood vessel smooth muscle cells to relax and dilate by increasing cGMP levels In sickle cell anemia 10% of red blood cells destroyed daily releasing hemoglobin Hemoglobin is an excellent scavenger of NO This may be the cause of some of the pain of sickle cell anemia
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04-28 - 04/28/09 Major neurotransmitters o o o o...

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