{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Chapter 13 - Chapter 13. NMR"for his development...

Info icon This preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Chapter 13. NMR "for his development of nuclear magne<c resonance spectroscopy for determining the three ­dimensional structure of biological macromolecules in solu<on" Kurt Wüthrich Switzerland Eidgenössische Technische Hochschule (Swiss Federal Ins<tute of Technology) Zurich, Switzerland Nuclear magne<c resonance Chemical shiMs The posi<on of an absorp<on on the horizontal axis is called its chemical shiM. Reference: TMS Electron alignment by magne<c field Energy difference upon alignment Understanding chemical shiM Units of chemical shiMs: ppm Study Problem 13.2: An unknown compound with the molecular formula C5H11Br has an NMR spectrum consis<ng of two resonance: one at δ=1.02 (rela<ve integral 8378 units), and the other at δ=3.15 (rela<ve integral 1807 units). Propose a structure for this compound. n+1 spli^ng rule Mul<plica<ve spli^ng 1 ­bromo ­3 ­chloropropane NMR of alkenes Problem 13.24 Carbon NMR NMR spectra of alcohol NMR solvents: CCl4, CDCl3, CD2Cl2 Hydrogen ­bonding D2O shake (exchange) D2O shake subs<tutes a hydrogen by deuterium, elimina<ng its resonance form proton NMR and the spli^ng that the hydrogen causes. NMR Spectrometer Key Points •  NMR basic concept: nuclear magne<c resonance, opera<ng frequency, resonance absorp<on, chemical shiM; •  Physical basis: gyromagne<c ra<o, different energy of electrons with different spins; •  Physical basis of chemical shiMs and shielding; •  Effects of electronega<vity on proton chemical shiMs; •  Determina<on of unknown structures by NMR spectroscopy; •  Spin ­spin spli^ng; analysis of spli^ng; Informa<on about connec<vity; •  n+1 rule (excep<ons); •  Mul<plica<ve spli^ng; •  D2O shake; applica<on of simplifying NMR spectra of alcohols; •  NMR characteris<cs of alkenes, alkanes and cycloalkanes; •  Carbon NMR. ...
View Full Document

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern