Lecture 2.15 Notes

Lecture 2.15 Notes - 2/15/10 Chemical machines and coding...

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2/15/10 Chemical machines and coding devices Historical perspective: the genetic enigma of the early 20th century How is the genetic algorithm transmitted to progeny? The structural complexity of proteins and the paradox of a hypothetical enzyme-mediated mechanism of protein biosynthesis Protein sequences must be specified by genes: what are they made of and how do they function? The structural complexity of proteins: proteins are chains of amino acids. There are 20 different amino acids, therefore, for an average sized protein of 300 amino acids there are 20 300 possible permutations of sequence. If proteins were synthesized enzymatically each new amino acid residue that was added to the growing chain would require a separate enzyme. Thus, for our average sized protein, 300 enzymes would be required to synthesize a single protein. Genotype ó phenotype: properties of proteins are heritable traits and properties depend on amino acid sequence. Thus, sequence of proteins is a heritable trait.
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Lecture 2.15 Notes - 2/15/10 Chemical machines and coding...

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