Lecture 3.5 - Regulation of Gene Expression...

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Regulation of Gene Expression Sensing and Signal Transduction:  Chemotaxis Control of Transcription in Archaea Global Control and the lac  Operon The Stringent Response Other Global Networks Regulation of Development in Model Bacteria Bacillus Caulobacter RNA-Based Regulation Antisense RNA Riboswitches The trp  attenuater
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Repellants Transducer (MCP) Cell wall Flagellar motor Cytoplasmic membrane Cytoplasm Response to signal Adaptation
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Sensory receptors Sensory proteins in the cell membrane: methyl-accepting chemotaxis proteins (MCPs) 5 MCPs identified in E. coli, each of which can bind a variety of compounds
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Response to signal MCP cytoplasmic domain forms complex with CheW and CheA (sensor kinase ) Binding of ligand affects autophosphorylation activity of CheA. o Attractants decrease activity  o Repellants increase activity Attractants - CheA Repellants - CheA-P
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Interaction with flagellar motor CheA-P phosphorylates CheY (response regulator) CheY-P interacts with flagellar motor to induce clockwise rotation (tumbling) CheZ (phosphatase) dephosphorylates CheY
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Response to signal summary Attractant ↑ CheY-P↓ CCW rotation (run) Attractant ↓ CheY-P↑ CW rotation (tumble)
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Adaptation MCPs affinity for ligand is altered by covalent modification (methylation). Methylation makes MCPs
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Lecture 3.5 - Regulation of Gene Expression...

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