Absorption

Absorption - Membrane Transport Ficks Law Flux = P*A...

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Membrane Transport
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Fick’s Law Flux = P*A (Cout-Cin) if Cout > Cin net flux moves in if Cin>Cout net flux moves out Conc = 0 at start of dosing Membrane Outside fluid Inside fluid Drug conc Low partition High partition High partition=steep gradient=fast Low partition=shallow gradient=slow
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Fick’s Law Flux = P*A* (Cout-Cin) there must be a lipid solubility term in P – Flux= R*T* α *1/f im *1/ x*A*(Cout-Cin) R = gas law constant! T=temp α =part coeff into membrane (why?) f im =friction drug – membrane x – membrane thickness A – surface area
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Fick’s Law Flux is NET flux if change in # molecules down if molecules diffuse out up if molecules diffuse in Flux (net)=P*A*(Cout-Cin) Flux (net)= P*A*Cout – P*A*Cin = Unidirectional IN – Unidirectional OUT Concentration is a driving force Inside Outside
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Unidirectional flux = P*A*Cout (for example) It’s linearly proportional to the concentration FIRST ORDER
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Absorption - Membrane Transport Ficks Law Flux = P*A...

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