Clearance I

Clearance I - Can Cl r exceed 1.3 L/min? What if Cl r =...

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Clearance - I
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Clearance What is it – Theoretical volume that is totally cleared of drug per unit time It’s theoretic – may not actually work this way It’s useful
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Clearance Example Amount Remaining versus Time Time 0 5 10 15 20 25 30 Amount Remaining 0 200 400 600 800 1000 1200
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Clearance Theoretic Amount Remaining versus Time Time 0 5 10 15 20 25 30 Amount Remaining 0 200 400 600 800 1000 1200
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Clearance - Example 1 Liter Body Water 20% per minute 200 ml/min = 0.2 L/min What if removed 200 ml/min, but only cleared one half of the drug??
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Clearance Biology Liver by metabolism – Cl m Liver blood flow ~ 1.5 L/min – Can Cl m exceed 1.5 L/min? – What if Cl m = 0.3 L/min? And if fu=0.2?
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Clearance Biology Kidney- Renal elimination – Cl r Renal bloodflow ~1.3 L/min
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Unformatted text preview: Can Cl r exceed 1.3 L/min? What if Cl r = 0.26 L/min? What if fu=0.2? Continuous/Multiple Dosing Amount Present versus Time Time 5 10 15 20 25 Amount Present 5 10 15 20 Continuous/Multiple Dosing Amount Present versus Time Time 5 10 15 20 25 Amount Present 5 10 15 20 Continuous/Multiple Dosing Amount Present versus Time Time 0 5 10 15 20 25 Amount Present 5 10 15 20 Quantitative Relationships Amount reaches a steady state Steady state depends on Rate of Administration - R A Rate of Excretion - R E Clearance proportionality constant C ss,avg = R A / Cl T Inverse if clearance reduced, Css increases...
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This note was uploaded on 08/26/2010 for the course PHRM 231 taught by Professor N/a during the Fall '07 term at UConn.

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Clearance I - Can Cl r exceed 1.3 L/min? What if Cl r =...

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