Dosing+Regimen+Design+Constant+Infusion

Dosing+Regimen+Design+Constant+Infusion -...

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Dosing Regimen Design
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Constant Infusion Biological Factors Stability of drug, no first pass, etc. Kinetic Factors Very precise control possible Fast half-life drugs  Disadvantages Invasive, etc.
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Plateau Value Change in Body = Rate in – Rate out dA/dt = R 0  - kA A k R 0 R 0  = Infusion rate k = first order rate constant A = amount in body
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Plateau Value – Steady State Change in Body = Rate in – Rate out = 0 dA/dt = R 0  – kA = 0    R 0  = kA   A ss =R 0 / k A k R 0
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Plateau Value – Steady State dA/dt = R 0  – kA = 0  at steady state A = C p  * V , insert on both sides dC p *V/dt = R 0  – kC p *V = R0 – (k*V)C p V*dC p /dt = R 0  – Cl*C p =  0 C p,ss  = R 0 /Cl     Which we have seen  before A k R 0
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Steady state depends on: Infusion Rate and Clearance (or elimination k) How Change C p,ss? Alter the infusion rate
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Dosing+Regimen+Design+Constant+Infusion -...

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