Drug+Interactions+Pharmacodynamics

Drug+Interactions+Pharmacodynamics - Drug Interactions,...

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Drug Interactions, Pharmacodynamics
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Practice Problems Drug Monograph 10 in text Phenytoin You should understand the explanatory text Drug Monograph 14 Valproic Acid Questions 1-3
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An example- Q3 p 445 in text S.N. a 23 y.o. 70-kg woman is receiving phenobarbital 60 mg BID and phenytoin 300 mg QD. The steady-state plasma drug concentrations are 18 mg/L for phenobarbital and 10 mg/l for phenytoin. Because of poor seizure control, valproic acid 500 mg every 8 hours was added to this drug treatment regimen.
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An example- Q3 p 445 in text Two months later, SN complained of drowsiness. At that time plasma drug concentrations were measured and reported as follows: phenobarbital 30 mg/L (previous 18 mg/L), phenytoin 6 mg/L (previous 10 mg/L) and valproic acid 75 mg/L. How can increased phenobarbital and decreased phenytoin concentration be explained?
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Drug-Drug PK Interaction Can be complicated Interactions can cause increase or decrease Cp Recognize potential mechanisms for interactions
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Drug+Interactions+Pharmacodynamics - Drug Interactions,...

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