Multiple+Dosing

# Multiple+Dosing - Multiple Dosing Practical Question Beth R...

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Unformatted text preview: Multiple Dosing Practical Question Beth R (63 yo, 58 kg) is to receive oral multiple dose mexiletine for arrhythmia. I ts clearance is 0.5 L/h/kg and V=6L/kg. I ts recommended to avoid peak to trough fluctuations. Oral dosage forms are 150, 200 and 250 mg and oral bioavalability is 0.9. I f want average plasma conc to be 1 mg/k with peak to trough of 0.75-1.5 ml/L what is appropriate dosing regimen? Yet Another A patient started on mulitple iv dose regime of antibiotic to be given by short (30 min) iv infusions. I t is desired to have peak-trough concentations of 10 and 1 mg/L. The elimination rate constant is 0.184 min -1 and the volume of distribution is 15 L. Optimize to dosing regimen to achieve the therapeutically targeted concentrations (e.g. dose, dosing interval) Hang on to you hats boys and girls Need to develop quantitative relationships for Plasma concentration versus time Average plasma concentration Peak/trough plasma concentration Dosing interval prediction Dose selection Time to steady state, need loading dose? Optimal dosing regimen Heres where we are going D = dose, V=vol. dist.n=# doses, tau=dosing interval, and k=first order elimination constant C p,n = * e kt * 1-e-n*k*tau D V 1-e-*k*tau Which looks worse than it really is Lets Give 160 mg every t 1/2 160 -> 80 + 160...
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## This note was uploaded on 08/26/2010 for the course PHRM 231 taught by Professor N/a during the Fall '07 term at UConn.

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Multiple+Dosing - Multiple Dosing Practical Question Beth R...

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