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Routes Lecture - Pharmacokinetics No model is right but...

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Pharmacokinetics No model is right but many are useful
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GI Tract Feces Bile LIVER P L A S M A LUNG NOSE MUSCLE SKIN Kidney Urine Inter- Intra- stitial cellular 15% 40% 5% Total=60% BW (includes liver, lung etc) ..................... ..................... ....................... ................................ Absorption Excretion Distribution
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GI Tract Feces Bile LIVER P L A S M A LUNG NOSE MUSCLE SKIN ..................... ..................... ....................... ................................ Absorption IV DERMAL IM SC ORAL Inhalation Rectal
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Interstitial Intracellular - After iv, im or sc injection
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Interstitial Intracellular Any epithelium respiratory, GI tract, skin
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GI Tract Feces Bile LIVER P L A S M A LUNG ..................... ..................... ....................... ................................ ORAL Absorption
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Feces Bile LIVER P L A S M A Stomach ~ 1hr pH ~ 2 Esophagus quick! Small Intestine 3-5 hr pH - neutral active transport LargeIntestine 12-18 hr pH - neutral active transport Rectum Absorption
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Feces LIVER P L A S M A ORAL Stomach ~ 1hr pH=2 Esophagus quick! Drug Small Intestine 3-5 hr pH - neutral active transport Drug LargeIntestine 12-18 hr pH - neutral active transport Rectum Drug Drug Metabolite Metabolite
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