Special+Populations

Special+Populations - Special Populations Age Body Wt Liver...

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Special Populations
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Age, Body Wt Liver Disease Renal Disease Dialysis
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Point of Reference Average Age Can be drug specific 55 y.o. is typical assumption, e.g. “typical adult” Ignore age if + 20 yrs from average
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Point of Reference Ideal Body Wt Men: 50 + 0.91*(ht in cm-152) Women: 45 + 0.91 *(ht in cm-152) When to consider body wt Child, or if adult is petite, emaciated or obese Need for body wt correction is drug specific (e.g. lipid soluble vs polar drugs in obese?) Drug clearance usually not altered by adipose tissue (except glucuronidation which is increased)
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Absorption Typically not a huge difference with age Are some changes Low gut acid until ~ 3 yo Neonate, elderly Tend to slow gastric emptying, slow peristalsis
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Total body water/kg Tends to remain constant during development fu tends to be higher in neonate than adult Stays fairly constant throughout adulthood V D Tends to stay constant in adulthood (ex. obese)
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This note was uploaded on 08/26/2010 for the course PHRM 231 taught by Professor N/a during the Fall '07 term at UConn.

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Special+Populations - Special Populations Age Body Wt Liver...

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