Two+Compartment+Models

# Two+Compartment+Models - Compartmental Models OneTwo...

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Compartmental Models One Two Compartments 1

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Practice Problems Equation List Which equations do we use? 2
After termination of an intravenous constant rate infusion the plasma concentration of a drug declines mono- exponentially (C=C*e -kt ). Concentrations measured 2 and 12 hours after the end of the infusion are 12.9 mcg/L and 6.0 mcg/L, respectively. Calculate the initial concentration at the end of the infusion, and predict the concentration 24 hours after termination of the infusion. If the infusion was of 1 hr duration what was the infusion rate (assume V D =4L). 3

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Edgar W (20 yo 58 kg) is receiving 80 mg of gentamicin as an iv infusion over a 30 min period q8hr. Two plasma samples are obtained to monitor serum concentrations as follows: 30 min after the end of the infusion and 30 min before the next dose. The plasma concentrations at these times are 4.9 and 1.7 mg/L. Assume a steady state. Develop a reasonable dosing regimen that will produce peak and trough concentrations of approx. 8 and 1 mg/L respectively. 4
Two Compartments V i V t k e Drug given into “initial” volume (V i, central compartment) and it slowly distributes into larger “tissue” volume (V t, peripheral compartment) Drug Eliminated from the central compartment (Pages 23-26 in you text) 5

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When do we see this? V i V t k e Partitions slowly into a “large” compartment lots of tissue binding (f u,p and f u,t ) What if these occur and drug “slowly” permeable binding in tissue and low lipid solubility/charged Very lipid soluble – partitions into fat low blood flow into fat tissues so this process is 6
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