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Unformatted text preview: Compartmental Models One Two Compartments 1 Practice Problems • Equation List • Which equations do we use? 2 • After termination of an intravenous constant rate infusion the plasma concentration of a drug declines monoexponentially (C=C*ekt ). Concentrations measured 2 and 12 hours after the end of the infusion are 12.9 mcg/L and 6.0 mcg/L, respectively. Calculate the initial concentration at the end of the infusion, and predict the concentration 24 hours after termination of the infusion. If the infusion was of 1 hr duration what was the infusion rate (assume V D =4L). 3 • Edgar W (20 yo 58 kg) is receiving 80 mg of gentamicin as an iv infusion over a 30 min period q8hr. Two plasma samples are obtained to monitor serum concentrations as follows: 30 min after the end of the infusion and 30 min before the next dose. The plasma concentrations at these times are 4.9 and 1.7 mg/L. Assume a steady state. Develop a reasonable dosing regimen that will produce peak and trough concentrations of approx. 8 and 1 mg/L respectively. 4 Two Compartments V i V t k e Drug given into “initial” volume (V i, central compartment) and it slowly distributes into larger “tissue” volume (V t, peripheral compartment) Drug Eliminated from the central compartment (Pages 2326 in you text) 5 When do we see this? V i V t k e Partitions slowly into a “large” compartment lots of tissue binding (f u,p and f u,t ) What if these occur and drug “slowly” permeable binding in tissue and low lipid solubility/charged Very lipid soluble – partitions into fat low blood flow into fat tissues so this process is 6 Plasma Time Course...
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This note was uploaded on 08/26/2010 for the course PHRM 231 taught by Professor N/a during the Fall '07 term at UConn.
 Fall '07
 n/a

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