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Two+Compartment+Models+Part+II

# Two+Compartment+Models+Part+II - Compartmental Models One...

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Unformatted text preview: Compartmental Models One Two Compartments 1 Problem of the Day • A 70 y.o. is to be treated with digoxin tablets. What should the daily dose (in mg) be to achieve and maintain a target plasma level of 1 ng/ml? How long will it take to achieve 90% of plateau values? You can assume: Cl R =41.5 mL/min (for digoxin) in this 43 kg patient, f e =0.68;Vss=6.7 L/kg; F=0.75. Two Compartments V i V t k e Drug given into “initial” volume (V i, central compartment) and it slowly distributes into larger “tissue” volume (V t, peripheral compartment) Drug Eliminated from the central compartment (Pages 23-26 in you text) 3 Plasma Time Course Log Plot – Not a straight line! Looks like there is a fast phase ( α )and a slow phase ( β ) Time 2 4 6 8 10 12 14 AMOUNT 1 10 100 α β 4 Conceptual Approximation • Fast phase – α – Distribution into peripheral compartment – t ½ for distribution • Slow phase = β – Elimination from the peripheral compart. – t ½ for elimination • Not precisely correct mathematically • (What if distribution is slower than elimination?) 5 It’s the sum of two lines (exponentials) Long times – it’s just the slower phase (elimination), fast phase has petered out Early times – plasma curve is balance of slow and fast phase (both occuring) can strip out the slow phase to reveal the fast phase Time 5 10 15 20 25 30 AMOUNT 1 10 100 α β 6 Initially drug “only” distribution through small Vi (e.g. plasma) slowly drug distributes into the tissues (peripheral comp.) What is V...
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Two+Compartment+Models+Part+II - Compartmental Models One...

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