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Volume+of+Distribution II

Volume+of+Distribution II - Volume of Distribution II Last...

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Volume of Distribution - II
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Last Time V of distribution “Vd” or just “V” Cp = Absorbed Dose/V V = Absorbed dose/Cp Loading Dose LD = Cp * Vd/(F*S) Can just use “V” (not “Vd”) – LD= C p * V/ (F*S) _____________________ (assumes no excretion)
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V and Dosing Incremental Loading Dose = V * (C p desired - Cp initial )/(S*F) Patient has Cp at one level, but want to increase it to a new level ________________________ assumes no excretion
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Factors Influencing V How far it distributes into which compartments Lipid solubility highly lipid soluble, fat, V is high Protein binding to plasma proteins – V low to tissue proteins – V will be high
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Protein Binding Plasma Tissue Drug*Prot Drug Drug Drug*Prot + + Prot Prot
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Plasma Protein Binding Clinically “blood” concentration is total not free Has important implication w.r.t. dosing Can change in certain diseases or from person to person Need to understand to prevent over or under dosing
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Plasma Protein Binding Only Free drug interacts with receptor total drug indirect measure of free fu = Free drug/Total drug = C free /(C bound +C free ) Binding proteins
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