ch369_ch 11-tca

ch369_ch 11-tca - Imagine if instead of metabolizing...

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Imagine, if instead of metabolizing glucose to pyruvate using enzymes, we burned glucose in oxygen: C 6 H 12 O 6 + 6O 2 ====> 6CO 2 + 6H 2 O + energy How much energy could we get burning glucose in O 2 ? Enough for about 80 ATPs. How much ATP did we make in glycolysis?
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Glycolysis: oxidizes glucose to pyruvate. glucose ===> 2 pyruvates (makes 2 ATPs)
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Oxidize the pyruvate from glycolysis all the way to CO 2 . This is what the TCA cycle does. (also known as tricarboxylic acid cycle or Krebs cycle or citric acid cycle) Next:
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Chapter 11 - The citric acid cycle The citric acid cycle naturally follows glycolysis, since it describes something that pyruvate can be used for! Known as the “ citric acid cycle ” or “ Krebs cycle ” or tricarboxylic acid cycle ” or “ TCA cycle ”.
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In eukaryotic cells, the citric acid cycle happens in the mitochondria. mitochondria Where does the citric acid cycle occur? A eukaryotic cell
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Before entering the citric acid cycle, 2 carbons from the pyruvate (from glycolysis) are used to make “acetyl coenzyme A”. pyruvate + NAD + + CoA =======> acetyl CoA + NADH + CO 2 pyruvate dehydrogenase complex 3 C’s 2 C’s one C
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Coenzyme A and acetyl-CoA. CoA Acetyl CoA
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Coenzyme A and acetyl-CoA. CoA Acetyl CoA From vitamin B5 (pantothenic acid)
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pyruvate + NAD + + CoA =======> acetyl CoA + NADH + CO 2 pyruvate dehydrogenase complex The pyruvate dehydrogenase complex (PDC) is enormous!
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pyruvate + NAD + + CoA =======> acetyl CoA + NADH + CO 2 pyruvate dehydrogenase complex E. coli PDC has 60 subunits, and mammalian PDC has about 140
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ch369_ch 11-tca - Imagine if instead of metabolizing...

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