ch369_ch 18-DNA damage

ch369_ch 18-DNA damage - Career advice. Identify something...

Info iconThis preview shows pages 1–13. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Career advice. Identify something that you are passionate about (or at least interested in). Do it was well as you can. Try to Fgure out a way to get paid to do it. DNA damage & repair Chapter 18 One example of DNA damage- adjacent thymines can be cross- linked by UV light. DNA with cross-linked thymines may not replicate correctly. Unnumbered, page 562 (2) Oxidative modification of DNA. An example of DNA damage- oxidation of Guanine. Depurination is a type of DNA damage. Non-enzymatic hydrolysis of N- glycosidic bond (A & Gs sometimes lose their bases) DNA Repair Mechanisms Mismatch repair Base excision repair Nucleotide excision repair Recombination Figure 18.04 The mismatch repair protein MutS bound to DNA. Mismatch Repair Proteins Scans DNA for mismatches (such as non-Watson-Crick base-pairings due to a damaged base) and repairs mismatch. Figure 18.05. Base-excision repair . (oxidized G, for example) Nucleotide excision repair Figure 18.09 Homologous recombination is a repair mechanism that can fx double-strand breaks . Proteins that coordinate this repair process are always present in bacteria and eukaryotes (they are constituitively expressed ). BRCA1 (a breast cancer associated protein) participates in DNA break repair. Mutations in BRCA1 compromise the repair mechanism, resulting in signifcantly elevated breast cancer risk. Figure 18-12. Cancer cells Abnormal kinase activity ==> abnormal cell cycle (cells divide too often). Apoptosis (cell death) signals dont work properly ==> damaged cells dont die when they should. Angiogenesis ==> cancer cells produce signals for blood vessel growth, which supplies nutrients to the abnormally dividing cells. Some anti-cancer drugs have specifc protein targets ( Gleevec)....
View Full Document

This note was uploaded on 08/26/2010 for the course CH 369 taught by Professor Kbrowning during the Spring '07 term at University of Texas at Austin.

Page1 / 34

ch369_ch 18-DNA damage - Career advice. Identify something...

This preview shows document pages 1 - 13. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online