{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

ch369_ch 18-DNA damage

ch369_ch 18-DNA damage - Career advice Identify something...

Info icon This preview shows pages 1–13. Sign up to view the full content.

View Full Document Right Arrow Icon
Career advice. Identify something that you are passionate about (or at least interested in). Do it was well as you can. Try to figure out a way to get paid to do it.
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
DNA damage & repair Chapter 18
Image of page 2
One example of DNA damage - adjacent thymines can be cross- linked by UV light. DNA with cross-linked thymines may not replicate correctly.
Image of page 3

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Unnumbered, page 562 (2) Oxidative modification of DNA. An example of DNA damage - oxidation of Guanine.
Image of page 4
Depurination is a type of DNA damage. Non-enzymatic hydrolysis of N- glycosidic bond (A & G’s sometimes lose their bases)
Image of page 5

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
DNA Repair Mechanisms Mismatch repair Base excision repair Nucleotide excision repair • Recombination
Image of page 6
Figure 18.04 The mismatch repair protein MutS bound to DNA. Mismatch Repair Proteins Scans DNA for mismatches (such as non-Watson-Crick base-pairings due to a damaged base) and repairs mismatch.
Image of page 7

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Figure 18.05. Base-excision repair . (oxidized G, for example)
Image of page 8
Nucleotide excision repair Figure 18.09
Image of page 9

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Homologous recombination is a repair mechanism that can fix double-strand breaks . Proteins that coordinate this repair process are always present in bacteria and eukaryotes (they are constituitively expressed ”). BRCA1 (a breast cancer associated protein) participates in DNA break repair. Mutations in BRCA1 compromise the repair mechanism, resulting in significantly elevated breast cancer risk. Figure 18-12.
Image of page 10
Cancer cells Abnormal kinase activity ==> abnormal cell cycle (cells divide too often). Apoptosis (cell death) signals don’t work properly ==> damaged cells don’t die when they should. Angiogenesis ==> cancer cells produce signals for blood vessel growth, which supplies nutrients to the abnormally dividing cells.
Image of page 11

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Some anti-cancer drugs have specific protein targets (Gleevec).
Image of page 12
Image of page 13
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern