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ch369_sum10_enz_1_notes

ch369_sum10_enz_1_notes - Onward to chapter 6 Enzymes...

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Enzymes - Biological Catalysts (with chymotrypsin as an example) Onward to chapter 6 !
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Example of a useful biochemical reaction: Peptide bond hydrolysis . peptide hydrolysis reaction: This reaction takes years without a catalyst.
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Example of a useful biochemical reaction: Peptide bond hydrolysis . peptide hydrolysis reaction: This reaction takes years without a catalyst.
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Ways to increase reaction rates of slow reactions: 1) increase the temperature !! (not very practical for living things) 2) use enzyme as a catalyst to lower the activation energy of a reaction
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Chymotrypsin catalyzes peptide bond hydrolysis.
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Protease - cleaves peptide bonds (example = chymotrypsin). Transferase - transfers a functional group. Isomerase - converts one isomer to another. Ligase - Joins 2 molecules together. Example: DNA ligase (requires ATP) etc. Some classes of enzymes
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How do enzymes increase reaction rates? By lowering the free energy of the transition state.
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An enzyme can raise the local concentration of reactants (by binding them close together), and orient them most effectively for a reaction to occur. Enzymes contain “ active sites ” where substrates bind and the chemical reaction takes place.
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Chymotrypsin - catalyzes peptide bond hydrolysis.
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