{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

ch369_sum10_glycol_1_notes

ch369_sum10_glycol_1_notes - Chapter 10 Glucose...

Info icon This preview shows pages 1–9. Sign up to view the full content.

View Full Document Right Arrow Icon
Chapter 10 - “Glucose metabolism” (glycolysis) What is glycolysis? The metabolic pathway that converts glucose to pyruvate. Produces ATP (which is very useful). Overall reaction of glycolysis:
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
10 steps in glycolysis. Each step is catalyzed by its own enzyme. Will make a few comments on each step. Glycolysis is regulated. glucose 2 pyruvate
Image of page 2
Step 1: glucose converted to glucose-6-phosphate by hexokinase . This uses ATP. What ??? I thought we were supposed to make ATP !!!
Image of page 3

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
The first 5 steps in glycolysis are sometimes called “preparatory phase” or “energy investment phase”. Our text uses “ energy investment phase ”. Last 5 steps in glycolysis are called “generation phase” or “energy payoff phase”. Our text uses “ energy payoff phase ”. The last 5 steps are where the ATP is made.
Image of page 4
Hexokinase catalyzes step 1. Step 1 releases a lot of energy (therefore is essentially irreversible). ( Δ G = -16.7 kJ/mole)
Image of page 5

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Phosphoglucose isomerase catalyzes step 2. Δ G for this step is very small (1.6 kJ/mole). This means the reaction is reversible, and reactant and product are both present, at equilibrium.
Image of page 6
I suppose it is worth mentioning that glucose is an “aldose”, fructose is a “ketose”. Above, glucose and fructose are drawn as “Fischer projections”.
Image of page 7

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Phosphofructokinase catalyzes step 3. Oh no, we just used another ATP! Clearly, this is still the “preparatory phase” of glycolysis.
Image of page 8
Image of page 9
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern