ch369_sum10_glycol_1_notes

ch369_sum10_glycol_1_notes - Chapter 10 - “Glucose...

Info iconThis preview shows pages 1–9. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Chapter 10 - “Glucose metabolism” (glycolysis) What is glycolysis? The metabolic pathway that converts glucose to pyruvate. Produces ATP (which is very useful). Overall reaction of glycolysis: 10 steps in glycolysis. Each step is catalyzed by its own enzyme. Will make a few comments on each step. Glycolysis is regulated. glucose 2 pyruvate Step 1: glucose converted to glucose-6-phosphate by hexokinase . This uses ATP. What ??? I thought we were supposed to make ATP !!! The frst 5 steps in glycolysis are sometimes called “preparatory phase” or “energy investment phase”. Our text uses “ energy investment phase ”. Last 5 steps in glycolysis are called “generation phase” or “energy payoFF phase”. Our text uses “ energy payoFF phase ”. The last 5 steps are where the ATP is made. Hexokinase catalyzes step 1. Step 1 releases a lot of energy (therefore is essentially irreversible). ( Δ G = -16.7 kJ/mole) Phosphoglucose isomerase catalyzes step 2. Δ G for this step is very small (1.6 kJ/mole). This means the reaction is reversible, and reactant and product are both present, at equilibrium. I suppose it is worth mentioning that glucose is an “aldose”, fructose is a “ketose”. Above, glucose and fructose are drawn as “Fischer projections”. Phosphofructokinase catalyzes step 3. Oh no, we just used another ATP! Clearly, this is still the “preparatory phase” of glycolysis....
View Full Document

This note was uploaded on 08/26/2010 for the course CH 369 taught by Professor Kbrowning during the Spring '07 term at University of Texas at Austin.

Page1 / 35

ch369_sum10_glycol_1_notes - Chapter 10 - “Glucose...

This preview shows document pages 1 - 9. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online