ch369-ch 14-lipids 2 - Lipid metabolism - Part II....

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Unformatted text preview: Lipid metabolism - Part II. (continuing in chapter 14) Quick summary of some of the most important points from last time. Liprotein lipases (or just lipases) are enzymes that cleave triacylglycerols (TAGs) to produce fatty acids (FAs). Fatty acids (FAs) cross cell membranes & enter cells, TAGs dont cross membranes so easily. Fatty acid activation means linking the FA to CoA forming acyl-CoA. FAs are attached to carnitine in cytosol, & then moved to mitochondrial matrix by carnitine shuttle . FA oxidation occurs in mitrochondrial matrix. In matrix, FAs are oxidized 2-carbon units at a time, by beta oxidation (a 4-step enzyme catalyzed cycle). Step 1, oxidation. Step 2, hydration. Step 3, oxidation. Step 4, thialysis. The 4 steps of beta oxidation: What are the most important products of beta oxidation ? Can enter TCA cycle. Lots of energy is released in oxidizing fatty acids ! peroxisomes - wikipedia. Peroxisomes oxidize fatty acids that cant be handled by the mitochondria (branched FAs, and FAs with more than 22 carbons). Fatty acid metabolism in peroxisomes. Fat metabolism in peroxisomes generates peroxide (toxic !!!), which is quickly converted to water by the enzyme catalase. Phytanate is an example of a branched FA that is processed in peroxisomes (phytanate comes from some chlorophylls). Green plants are a source of branched chain FAs. Biosynthesis of fatty acids. Fatty acid synthesis is in cytosol, and requires acetyl CoA....
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ch369-ch 14-lipids 2 - Lipid metabolism - Part II....

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