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General Physiology_Nohe_Date_042910

General Physiology_Nohe_Date_042910 - Dr Formnin Lecture...

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Dr. Formnin Lecture Chapter 15 Part A Blood Flow and the Control of Blood Pressure Heart is a pump dividided into the left heart and right heart Left is rich in oxygen and pumps it to the aorta and then the rest of the body Capillary system works to exchange oxygen and wastes with cells Then moves to the venule circulation, now poor in oxygen returns to the right heart, pulmonary artery to lungs, picks up oxygen and goes to the left heart Arteriole- rich in muscle layers with a lot of connective tissue provide resistance to blood flow o One level of blood flow regulation Blood Vessel Structure Largest artery- aorta highest oxygen has endothelium, elastic tissue, smooth muscle, and fibrous tissue (CT tissue) Arteriole- endothelium (epithelial tissue, cells can produce substance and cause contraction of smooth muscle layer), and smooth muscle Capillary – endothelium o Necessary for easy exchange between blood and interstitial fluid Venule- endothelium, fibrous tissue (CT tissue) Vein- lowest oxgen level, endothelium, elastic tissue, smooth muscle, fibrous tissue (CT tissue) Metarterioles Capillaries lack smooth muscle and elastic tissue reinforcement which facilitates exchange Metarterioles act as bypass channel and regulate flow into capillary beds Sphincters regulate contraction and exchange of blood into capillaries Microcirculation system- transfer from arteriole to capillaries to venule circulation Angiogenesis New blood vessel development Necessary for normal development Wound healing and uterine lining growth Controlled by cytokines o Mitogens: VEGF and FGF o Inhibitors: angiostatin and nedostatin Coronary heart disease o Collateral circulation Elastic Recoil in Arteries Needed to move blood through circulation Main force is contraction of the left ventricle Ventricle Contracts Semilunar valve opens Aorta and arteries expand and store pressure in elastic walls Relaxation
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Isovolumic ventricular relaxation Semilunar valve shuts, preventing flow back into ventricle Elastic recoil of arteries sends blood forward into rest of circulatory system Factors important in Flow Pressure, flow, resistance Proportional to pressure, inversely to resistance Blood flows only if a pressure gradient is present From higher to lower pressure
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General Physiology_Nohe_Date_042910 - Dr Formnin Lecture...

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