Unformatted text preview: o Affected individuals are BB or Bb o Males and females are equally affected and either may transmit the trait = no sex differences o Affected phenotype does not skip generation. Affected children have (at least one) affected parent(s) o Unaffected parents have unaffected children Except…a new mutation; Pedigree: An Autosomal Dominant Trait • The first thing you do with a pedigree is to count males and females • Example: Marfan syndrome phenotype – affects the skeletal system, cardiovascular system, and (near-sighted) eyes. Basketball and volleyball players have long legs and it’s found in those athletes. o Frequency – 1 in 10,000 o 25% of the cases are new mutations • Example: Huntington Disease o Frequency – 1 in 10,000 o Gene – Chromosome 4 o Protein – Huntington o Phenotype – affects the nerves to twitch, late onset disorder o Hh x hh o No treatment and no cure...
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This note was uploaded on 08/30/2010 for the course BISC 105 taught by Professor Patriciawalsh during the Spring '10 term at University of Delaware.
- Spring '10