Human Heredity and Development_Walsh_Date_042710

Human Heredity and Development_Walsh_Date_042710 -...

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Translocations composed of three steps o Initiation – translation begins at start codon o Elongation – tRNAs carry amino acids to growing peptide chain o Termination – translation ends at the stop codon DNA has information for making proteins What’s next? o Polypeptides fold Assisted by chaperones o Chemical modification Lipids = lipoprotein; CHO = glycoprotein which makes functional/final product of protein o Functional polypeptide = protein o Some secreted, some stay in cell Genes to proteins o Humans: 20,000 to 25,000 protein-coding genes o But make over 100,000 different proteins How? Alternate splicing – different exons Post translational modification Protein function is related to protein structure o Primary – sequence of amino acids o Secondary – localized interactions with hydrogen bonds between amino acids o Tertiary – (3) different areas starting to interact; ex. hydrogen, covalent bonding o Quaternary – more than one polypeptide
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