Human Heredity and Development_Walsh_Date_042910

Human Heredity and Development_Walsh_Date_042910 - Single...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Single base change in hemoglobin gene causes sickle cell disease: change in DNA change in sequence in beta globin polypeptide Other hemoglobin disorders o Hemoglobin variants (table 10.4) – affects the amino acid sequence , >400 identified, phenotypes range from harmless to lethal o Thalassemias (table 10.5) – synthesis of alpha or beta globin is reduced or absent Imbalance in the production of alpha or beta globin which affects transport of oxygen within the body; phenotype – mild lethal Alpha – reduced or absent synthesis of alpha globin; deletion of at least 1 alpha gene Treatment of Hb disorder o Fetal hemoglobin – two alpha globins and two gamma globins; gamma globins switched off at birth; beta gene is activated o Treatment with certain drug reactivates gamma genes; fetal hemoglobin produced MUTATION: SOURCE OF GENETIC VARIATION CHAPTER 11 What is a mutation? – heritable changes that get passed on; changes in DNA o Cause? – spontaneous errors often in DNA replication, ex. typo; we need to be
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

Page1 / 2

Human Heredity and Development_Walsh_Date_042910 - Single...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online