330-10 JP 14

330-10 JP 14 - BISC 330L Sp2010 Lect JP 14 Friday 12 Feb...

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BISC 330L Sp2010 Lect JP 14.ppt Friday 12 Feb 2010 Petruska Lecture 13 (Gibbs Free Energy) Cont’d Lecture 14: Enzyme Kinetics (Michaelis-Menten) Reference: BTS (6th ed.) Chap. 8
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Biochemistry Sixth Edition Chapter 8: Enzymes: Basic Concepts and Kinetics Copyright © 2007 by W. H. Freeman and Company   Berg • Tymoczko • Stryer Sections 8.3-8.4: Enzyme Kinetics
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Gibbs Free Energy Equation G = RT ln(Q/K eq ) = 2.303 RT log 10 (Q/K eq ) where Q is the general (Prod/React) form of K. At equilibrium: Q = K eq , G = 0 Under standard conditions: Q = 1, G = G o where G o = RT ln(1/K eq ) = - RT ln(K eq ) = - 2.3 RT log(K eq ) At room temperature: RT = 0.6 kcal/mole G o (in kcal/mole) = -1.38 log(K )
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Thus , ∆ G = G o + RT ln(Q) = G o + 2.3 RT log(Q where G o = - 2.3 RT log(K eq ) is the standard fre energy difference, when each reactant and each product is at 1 M concentration. Since biochemistry usually requires pH 7, i. e., [H + ] = 10 -7 M , rather than 1 M, one prefers to use a
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330-10 JP 14 - BISC 330L Sp2010 Lect JP 14 Friday 12 Feb...

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