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BISC 330 Spring 2010 Lecture 11

BISC 330 Spring 2010 Lecture 11 - B I SC 330L Biochemistr y...

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BI SC 330L: Biochemistry Spring Semester 2010 USC Lecture: Friday, 05 February 2010 1. Chapter 4: Flow of Genetic I nformatio Review RNA/DNA Structure Watson-Crick Proposal
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Chapter 4: DNA, RNA, and the Flow of Genetic Information DNA RNA PROTEIN
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The Watson- Crick Proposal DNA composed of two chains Two chains spiral around each other Sugar-phosphate backbone on the outside Bases situated inside double helix; perpendicular to long axis Major and minor grooves One turn of helix / 10 nucleotides Two chains are complementary and antiparallel H-bonds between bases Pyrimidines always pair with purines
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Importance of Watson- Crick Proposal 5’ 3’ 3’ 5’ Determining the structure had TWO important outcomes: 1. Gave rise to obvious and testable hypotheses about how genetic information could be stored. 1. Gave rise to the starting point for the development of techniques to study DNA
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Erwin Chargaff showed that base composition (%) varies from organism to organism. Organism A T C G E. coli 40 40 10 10 Human 30 30 20 20 Mycobacterium 15 15 35 35 Chargaff’s Rules: %A = %T and %G = %C BUT : (%A + %T) did NOT equal the (%G + %C)
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The General Structure of the Nucleotide The sugar in all nucleotides is a pentose sugar DNA and RNA each have four types of bases Without the phosphate group, it would be called a “nucleoside” Base P O Sugar
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Ribose vs. Deoxyribose RNA DNA
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