BISC 330 Spring 2010 Lecture 11

BISC 330 Spring 2010 Lecture 11 - BI SC 330L: Biochemistr y...

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Unformatted text preview: BI SC 330L: Biochemistr y Spr ing Semester 2010 USC Lectur e: Fr iday, 05 Febr uar y 2010 1. Chapter 4: Flow of Genetic I nfor matio Review RNA/DNA Str uctur e Watson-Cr ick Pr oposal Chapter 4: DNA, RNA, and the Flow of Genetic I nformation DNA RNA PROTEIN The Watson- Crick Proposal DNA composed of two chains Two chains spiral around each other Sugar-phosphate backbone on the outside Bases situated inside double helix; perpendicular to long axis Major and minor grooves One turn of helix / 10 nucleotides Two chains are complementary and antiparallel H-bonds between bases Pyrimidines always pair with purines I mportance of Watson- Crick Proposal 5 3 3 5 Determining the structure had TWO important outcomes: 1. Gave rise to obvious and testable hypotheses about how genetic information could be stored. 1. Gave rise to the starting point for the development of techniques to study DNA Er win Char gaff showed that base composition (%) varies from organism to organism. Or ganism A T C G E. coli 40 40 10 10 Human 30 30 20 20 Mycobacterium 15 15 35 35 Chargaffs Rules: %A = %T and %G = %C BUT : (%A + %T) did NOT equal the (%G + %C) The General Str ucture of the Nucleotide The sugar in all nucleotides is a pent ose sugar DNA and RNA each have four types of bases Without the phosphat e group, it would be called a nucleoside Base P O Sugar Ribose vs. Deoxyribose RNA DNA The Bases...
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This note was uploaded on 08/30/2010 for the course BIO 320 taught by Professor Wu during the Spring '10 term at USC.

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BISC 330 Spring 2010 Lecture 11 - BI SC 330L: Biochemistr y...

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