HNPCC Book Review New England Journal of Medicine

HNPCC Book Review New England Journal of Medicine - book...

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book reviews n engl j med 360;11 nejm.org march 12, 2009 1161 ing their capacity to inform limited. There is a dearth of attention to endoscopy in the book (natural orifice translumenal endoscopic surgery, for example, is not covered, and endoscopic sub- mucosal dissection is afforded scant attention), and the field of genetic epidemiology and the importance of molecular stratification for chemo- therapy ( ras mutations, for example) emerged too recently to have made it into the book. But that, of course, is a fundamental limitation of printed media, which in other ways remain the stalwart of information in medicine. This book should be part of the requisite armamentarium of informa- tion for the multidisciplinary teams that address gastrointestinal cancers. Finlay Macrae, M.B., B.S., M.D. Royal Melbourne Hospital Melbourne, VIC 3050, Australia [email protected] Hereditary Gynecologic Cancer: Risk, Prevention and Management Edited by Karen H. Lu. 285 pp., illustrated. New York, Informa Healthcare, 2008. $199.95. ISBN 978-1-4200-5287-9. I n 1925, a patient who was being trea ted by Alfred S. Warthin told him she was terrified she would die of “cancer of my female organs or bowels,” which she saw as a curse on her family. Sadly, this woman did indeed succumb to uterine cancer at an early age, following the fate of 17 of her relatives — and a pattern of inherited uterine and colon cancer that is now known as the Lynch syndrome. This case raises the question of wheth- er the outcome for a patient in this situation would be any different today, a challenge that is taken up in this superb compendium on heredi- tary gynecologic cancers. The book is focused on the two major conditions that cause hereditary gynecologic cancer: the Lynch syndrome and he- reditary breast–ovarian cancer syndrome, which are perhaps the most recognizable and the most preventable of cancer predisposition syndromes. In a series of chapters written by experts in the field, this book provides a synthesis of the literature that is relevant to the clinician seeking to manage the care of families with inherited gynecologic cancers. The authors note that the 5% of endometrial cancers and 10% of ovarian cancers that are clearly hereditary cause approxi- mately 2000 cases of ovarian cancer and 2000 cases of uterine cancer each year in the United States. These cancers could be predicted by ge- netic testing — and readers may be surprised to learn that hereditary uterine and ovarian cancers associated with the Lynch syndrome can often be identified under the microscope. An immunohistochemical test for proteins
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This note was uploaded on 08/30/2010 for the course BIO 320 taught by Professor Wu during the Spring '10 term at USC.

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HNPCC Book Review New England Journal of Medicine - book...

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