Cannabinoid_CB1_Receptor_Mediates_Fear_Extinct[1]

Cannabinoid_CB1_Receptor_Mediates_Fear_Extinct[1] -...

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Unformatted text preview: Cannabinoid CB1 Receptor Mediates Fear Extinction via Habituation- Like Processes Jenny Strefling Irina Nesterenko Michelle Ruth Ben Seicol What is CB1? Cannabinoid is a plant derived chemical Exert its effects through two cannabinoid receptors (CB1 & CB2) Modulate a variety of behavioral phenomena including stress, anxiety, learning and memory o Where is CB1?- All over the body- Plasticity of medial prefrontal cortex and basolateral amygdala response to extinction of fear How Do we Study Fear Extinction? Associative learning processes and non-associative learning processes are involved with both the generation and suppression of a fear-based reaction in response to a discrete stimulus, such as mice freezing when they hear a certain sound. Fear Expression o Pavlovian fear conditioning - Association forms between tone-punishment o Sensitization - "general increase in responsiveness to potentially harmful stimuli after an aversive/stressful experience."Sensitization - "general increase in responsiveness to potentially harmful stimuli after an aversive/stressful experience....
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This note was uploaded on 09/01/2010 for the course BB 10294 taught by Professor Politz during the Spring '10 term at WPI.

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Cannabinoid_CB1_Receptor_Mediates_Fear_Extinct[1] -...

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